Pasien Infark Miokard Akut pada Studi Penggunaan Obat Anti Platelet di RSUD Gambiran Kota Kediri
DOI:
https://doi.org/10.59680/medika.v2i1.923Keywords:
Acute Myocardial Infarction, Drug Use, Anti plateletsAbstract
The purpose of this study was to determine the pattern of drug use, potential interactions, and side effects of antiplatelet drugs in acute myocardial infarction patients in inpatient installations to reduce morbidity and mortality rates at Gambiran Hospital, Kediri City. This study is a non-experimental study with descriptive research design and retrospective data collection, data collection using purposive sampling method. Retrospective data collection based on medical record data of patients with acute myocardial infarction, this research was conducted from January to December 2020, so that the pattern of use of anti-platelet drugs in patients with acute myocardial infarction was a combination of aspirin 80 mg 1x1 with clopidogrel 75mg 1x1 (93%), with the route of drug administration orally. Analysis of potential drug interactions was carried out using the Drugs Interaction Checker and obtained 4 occurrences of major potential interactions and 10 occurrences of moderate potential interactions. The desired potential drug interaction was to prevent platelet aggregation. There was an undesirable potential drug interaction related to decreased antihypertensive effect of the drug, while potential drug interactions in the form of gastrointestinal bleeding and decreased renal function could not be determined.
References
Antmann EM, and Braunwald E. "ST SegmentElevationMyocardial Infacrtion." In Harisson's Cardiovascular Medicine, by Loscalzo J. New york, 2010.
Bautista, L. E. And Vera, L. M. "Antihypertensive Effects of Aspirin."Springer Science BusinessMedia,2010:281-289.
Baxter,Karen.StockleysDrugInteraction, Ninth Edition. UK: Pharmaceutical Press, 2010.
Borja,Ibanez,etal."ESCGuidelinesFor The Management Acute MyocardialInfarctionInPatients Presenting With St-Segment
Elevation."EuropianHeart Journal, 2017: 1-8. DrugInteractionChecker.2021. In:www.drugs.com/druginteractio n.html.
Farid, N.A, A Kurihara, and S.A Wringhton. "Metabolism and Disposition of the Thienopyridine A ntiplatelet Drugs Ticlopidine, Clopidogrel, and Prasugrel in Humans."TheJournalOfClinical Pharmacology, 2010: 126-142.
Firdaus, Isman. "Pharmacoivasive StrategyinAcuteSTEMI."Jurnal Kardiolodi Indonesia, Vol.34 No.4, 2011: 266-271.
Furie, L Karen. "Guidelines For The Prevetion Of Stoke In Patients WhithstrokeorTransientIschemic Attack."AHA/ASA guideline, 2011: 228.
Gao, Q, F Zheng, Y Guo, and B Yang. "EfficacyofAdenosineinPatients WithAcuteMyocardialInfraction UndergoingPrimaryPercutaneous Coronay Intervention."Medicine Journal, 2015: Vol.94 No.32.
Giannopoulus, Georgius, Spyridon Deftereos, Fotios Kolokathis, Loanna Xanthopoulou, John Lekakis, and Dimitrios Alexopoulos."P2Y12receptor Antagonist And Morphine: Pharmakokinetics And Pharmacodinamics."American Heart Association, 2016.
Juzar, Dafsah Arifa. pedomantatalaksana sindrom koroner akut. jakarta: indonesian heart association, 2018.
—. Pedoman Tatalaksana Sindrom KoronerAkut.Jakarta:Indonesian Heart Association, 2015.
Karalliedde, K, S, F, J. Clarke, U Collignon, and J Karalliede. Adverse Drug Interaction: A Handbook For Prescriber. Chennai:MacmillanPublishing Solution p, 596-627., 2010.
Mariam, S. "Evaluasi Kejadian Interaksi Obat Pada Pasien Rawat Inap GeriatriPenderitaGagalJantung."Sekolah Tinggi Ilmu Farmasi dan Industri, Bogor., 2016.
Muhammad, Gibran Rinaldi, and Pipin Ardhianto. "PROFIL FAKTOR RISIKO ATHEROSKLEROSIS PADA KEJADIAN INFARK MIOKARD DENGAN ST SEGMENTELEVASIDIRSUP DR KARIADI SEMARANG." MediaMedikaMuda,2015:849-858.
Muhibbah, Abdurahman Wahid, Rismia Agustina, and Oskiilliandri. "Karakteristik Pasien Sindrom Koroner Akut Pada Pasien Rawat Inap Ruang Tulip Di RSUD Ulin Banjarmasin."IndonesianJournal For Health Science, 2019: 6-12.
Rathburn, R Christ, and Michelle D Liedtke. "Antiretrovial Drug Interactions: Overview Of Interaction Involving New And Investigational Agents And The Role Of Therapeutic Drug Monitoring For Managemet."Pharmaceutic,2011:vol1,page 745-781.
Schwinghammer,TerryL. "Cardiovascular Disorders." In Pharmacotherapy Handbook, by BarbaraGWells,JosephTDipiro and Cecily V Dipiro, 37-47. New york: Mc Graw Hill, 2015.
Susilo. "Identifikasi Faktor Usia, Jenis Kelamin dengan Luas Infark MiokardPadaPenyakitJantung Koroner Di Ruang ICCU RSD DR. Soebandi Jember."The Indonesian Journal Of Health Science, 2015: Vol.6(1): 1-7.
Tatro,D.S.DrugInteractionFact:The AuthorityOnDrugInteraction. California: Wolters Kluwer Health, 2012.
Yusetyani, Lilik, and Nailis Syifa. "Studi Penggunaan Aspirin Dan Clopidogrel Pada Pasien Infark Miokard Akut."Jurnal Farmasi DanIlmuKesehatan,2014:83-87.
