Jumlah Leukosit, Trombosit, dan Kadar Kreatinin Pada Pasien Sepsis Covid-19 Di RSUD Genteng Banyuwangi Pada Periode 2020-2021

Authors

  • Rezita Nurul Magfiroh Universitas Airlangga Surabaya
  • Nur Septia Handayani Universitas Airlangga Surabaya
  • Erlinda Widyastuti Universitas Airlangga Surabaya
  • Belgis Belgis Universitas Airlangga Surabaya

DOI:

https://doi.org/10.59680/medika.v2i2.991

Keywords:

COVID-19, Creatinine, Leukocyte, Platelets, Sepsis

Abstract

One of the medical conditions that leads to the highest death rate worldwide is sepsis. In the presence of several variables and concomitant conditions, the mortality rate from sepsis keeps rising in proportion to the severity of the condition. It is quite concerning when sepsis patients have proven COVID-19. Some patient subgroups and inflammatory mediators may have increased cytokine release as a result of the SARS-CoV-2 virus. A number of laboratory tests can be used to diagnose COVID-19 and sepsis, one of which is counting leukocytes, platelets, and creatinine levels as indicators of organ failure. The purpose of this study is to characterize the platelet, leukocyte, and creatinine levels in individuals who have been diagnosed with COVID-19 sepsis. This study's methodology employed a descriptive observational technique using 36 patient samples from Genteng Banyuwangi General Hospital, selected based on laboratory examination results (leukocyte count, platelets, and creatinine levels), as well as characteristics related to gender, age, comorbidities, and hospital discharge status. The findings revealed that female patients aged 20 (55.6%) made up the bulk of patients with confirmed COVID-19 sepsis, whereas the largest age group consisted of 9 (56.25%) individuals who were over 60. Twenty-two (61.1%) sepsis patients with proven COVID-19 had a high leukocyte count, and of those with confirmed COVID-19 and sepsis, the majority had normal platelets depending on the platelet count. Nine (56.25%) male patients with confirmed COVID-19 sepsis had elevated creatinine levels, whereas 10 (50%) female patients had normal findings. Patients with sepsis who had verified COVID-19 were generally deceased upon hospital release, with no comorbidities in 14 patients (or 50% of the total), and diabetes mellitus in 13 patients (or 46.4%).

 

References

Abdi, M. Jalilian, P. A. Sarbarzeh and Vlaisavljevic. (2020)."Diabetes and COVID-19: A Systematic Review on The Current Evidence," Diabetes Research and Clinical Practice, Vol. 166, No. 108347, Pp. 1-13, 2020

Afzal A. (2020). Molecular Diagnostic Technologies for COVID-19:Limitations and Challenges. Journal Of Advanced Research. :149-59.

Aliviameita, A., Rinata, E., & Nadila, D. (2021). Korelasi Antara Profil Hematologi Dengan Procalcitonin Pada Pasien Terkonfirmasi COVID-19. The Journal of Muhammadiyah Medical Laboratory Technologist, 4(1), 66-73

Amgalan A, Othman M. (2020) Hemostatic Laboratory Derangements In COVID- 19 With A Focus On Platelet Count. Platelets, 31(6): 740–745

Angus, D. C., & Van Der Poll, T. (2013). Severe Sepsis and Septic Shock. N Engl J Med, 369, 840-851.

Annisa, M. P. (2020). Hubungan Jumlah Leukosit Dengan Kadar Glukosa Darah Pada Penderita Diabetes Melitus Tipe 2 (Doctoral Dissertation, Sekolah Tinggi Ilmu Kesehatan Nasional).

Baharoon, S., Telmesani, A., Tamim, H., Alsafi, E., Aljohani, S., Mahmoud, E., & Al-Jahdali, H. (2015). Community-Versus Nosocomial-Acquired Severe Sepsis And Septic Shock In Patients Admitted To A Tertiary Intensive Care In Saudi Arabia, Etiology And Outcome. Journal Of Infection And Public Health, 8(5), 418-424.

Balk, R. (2011). Roger C. Bone, MD and The Evolving Paradigms Of Sepsis. In Sepsis-Pro-Inflammatory And Anti-Inflammatory Responses (Vol. 17, Pp. 1-11). Karger Publishers.

Bastos ML, Tavaziva G, Abidi SK, Campbell JR, Haraoui L-P, Johnston JC, dkk. (2020). Diagnostic accuracy of serological tests for COVID-19: systematic review and meta-analysis. British Medical Jouenal.:370

Bone, R. C., Grodzin, C. J., & Balk, R. A. (1997). Sepsis: a new hypothesis for the pathogenesis of the disease process. Chest, 112(1), 235-243.

Caci G., A. Albini, M. Malerba, D. M. Noonan, P. Pochetti and R. Polosa. (2020) "COVID-19 and Obesity: Dangerous Lia isons, "Journal of Clinical Medicine, vol. 9, no. 2511, pp. 1-12.

Chan, J. F. W., Yuan, dkk. (2020). A Familial Cluster of Pneumonia Associated with the 2019 Novel CoronavirusIndicating Person-to-Person Transmission: A Study of a Family Cluster. The Lancet,395(10223), 514– 523. https://doi.org/10.1016/S0140-6736(20)30154-9

Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DK, dkk.(2020). Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Eurosurveillance. ;25(3):2000045.

David C. Dugdale (2013). Creatinine blood test. Available from: https://www.nlm.nih.gov/medlineplus/ency/article/003475.htm10.

Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., ... & Moreno, R. (2013). Surviving Sepsis Campaign: international guidelines for the management of severe sepsis and septic shock, 2012. Intensive care medicine, 39(2), 165-228.

Dear JW, Yasuda H, Hu X, Hieny S, Yuen PST, Hewitt SM, dkk. (2006). Sepsis- induced organ failure is mediated by different pathways in the kidney and liver: acute renal failure is dependent on MyD88 but not renal cell apoptosis. Kidney International;69:832-

Dong, Y., Dai, T., Wei, Y., Zhang, L., Zheng, M., & Zhou, F. (2020). A systematic review of SARS-CoV-2 vaccine candidates. Signal transduction and targeted therapy, 5(1), 1-14.

Fadillah, R., Nasrul, E., & Prihandani, T. (2021). Gambaran Pemeriksaan Kadar SGOT, SGPT, Ureum dan Kreatinin Pasien COVID-19 dengan dan tanpa Komorbid. Jurnal Kesehatan Andalas, 10(2), 107-113.

Favicon. (2011). Perbedaan Kadar Kreatinin Darah Sebelum dan Sesudah Aktivitas (Olahraga). Skripsi. Yogyakarta: Fakultas Sains dan Olahraga

Gaspar. 2015. Hubungan Peningkatan Angka Leukosit Pada Pasien Stroke Hemoragik Fase Akut Dengan Mortalitas di RSUD Dr. Abdul Aziz Singkawang. Skripsi. Universitas Tanjungpura

Guo, L. dkk. (2020) ‘Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)’, Clinical Infectious Diseases, 71(15), pp. 778–785.

Guo, T. dkk. (2020) ‘Clinical Characteristics of Elderly Patients with COVID-19 in Hunan Province, China: A Multicenter, Retrospective Study’, Gerontology, 66(5), pp. 467– 475

Hasma, R., Rikarni, R., & Yulia, D. (2021). Analisis Jumlah Trombosit Pada Pasien Terinfeksi Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2). Majalah Kedokteran Andalas, 44(5), 316-324.

Huang C, dkk.(2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. Erratum in: Lancet. (10223):497- 506.doi:10.1016/S0140-6736(20)30183-5

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., ... & Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet, 395(10223), 497-506.

Iskandar, A., & Siska, F. (2020). Analisis Hubungan Sequential Organ Failure Assessment (Sofa) Score Dengan Mortalitas Pasien Sepsis. Jurnal Kesehatan Andalas, 9(2), 168-173.

Kee, Joyce LeFever. 2007. Pedoman Pemeriksaan Laboraturium & Diagnostik. Edisi 6. EGC. Jakarta

KEMENKES RI. 2011. Pedoman Interpretasi Data Klinik, P. 15, Jakarta : Kementrian Kesehatan Republik Indonesia

Knotek M, Rogachev B, Wang W, Ecder T, Melnikov V, Gengaro PE, dkk. (2001) Endotoxemia renal failure in mice: role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney International;59:2243-9.

Kosack CS, Page A-L, Klatser PR. A guide to aid the selection of diagnostic tests. Bulletin of the World Health Organization (WHO). 2017;95(9):639.

Levy, M. M., Fink, M. P., Marshall, J. C., Abraham, E., Angus, D., Cook, D., ... & Ramsay, G. (2003). 2001 cm/cesium/accp/ats/sis international sepsis definitions conference. Intensive care medicine, 29(4), 530-538.

Madsen T. (2013). Sex differences in sepsis. Available from: http://sgwhc.org/ resources/professional education/case-studies/sex-differences sepsis/

Marshall, J. C. (2001). Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome. Critical care medicine, 29(7), S99- S106.

Martin LJ. (2014). Aging changes in immunity. Available from: https://www. nlm.nih.gov/medlineplus/ency/article/00 4008.htm

Mayr, F. B., Yende, S., & Angus, D. C. (2014). Epidemiology of severe sepsis. Virulence, 5(1), 4-11.

Meirina, Fathia.(2013) “Hematological Scoring System (HSS) sebagai Alat Uji Diagnostik Dini Sepsis pada Neonatus.” Tesis, Fakultas Kedokteran Universitas Sumatera Utara, Medan.

Nduka, O. O., & Parrillo, J. E. (2011). The pathophysiology of septic shock. Critical Care Nursing Clinics, 23(1), 41-66.

Osterbur, K., Mann, F. A., Kuroki, K., & DeClue, A. (2014). Multiple organ dysfunction syndrome in humans and animals. Journal of veterinary internal medicine, 28(4), 1141-1151.

Pawar, A., Raut, A., Kalrao, V., Jacob, J., Godha, I., & Thomas, R. (2016). Etiology and clinical outcomes of neonatal and pediatric sepsis. Archives of Pediatric Infectious Diseases, 4(2).

Prima., B., Gede., W & Novia., A., P. 2015. Hematologic Examination In PulmonaryTuberculosis Patient Admitted In General Hospital West Nusa Tenggara Barat Province In 2011-2012. Jurnal Kesehatan Masyarakat. Vol. 3. No.2. Hal. 27-37

Qian JY, Wang B, Liu C. (2020). Acute kidney injury in the 2019 novel coronavirus disease. Kidney Diseases.;323:1-6.

Ramírez, M. (2013). Multiple organ dysfunction syndrome. Current problems in pediatric and adolescent health care, 43(10), 273-277.

Ranzani, O.T., Shankar-Hari, M., Harrison, D.A., Rabello, L.S., Salluh, J.I., Rowan, K.M. and Soares, M., 2019. A comparison of Mortality from Sepsis in Brazil and England: The Impact of Heterogeneity in General and Sepsis- Specific Patient Characteristics. Critical care medicine,47 (1), pages 76-84

Remick, D. G. (2007). Pathophysiology of sepsis. The American journal of pathology, 170(5), 1435-1444.

Rosita L, Husodo AC. The Relationship of Sepsis Occurrence and The Reduction of Platelet Count: A Research in PKU Muhammadiyah Yogyakarta Hospital for The Period of January to December 2010. JHMN. 2015;17:26-31.

Rukman,2014 .Hematologi Dan Tranfusi. Pustaka Penerbit : Yogyakarta :14,125,127

Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., ... & Angus, D. C. (2016). The third international consensus definitions for sepsis and septic shock (Sepsis-3). Jama, 315(8), 801-810.

Snowden C, Kirkman E. 2002. The Pathophysiology of Sepsis. British Journal Anaesthesia. 2(1): 12-14

Spapen, H. (2008). Liver perfusion in sepsis, septic shock, and multiorgan failure. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology: Advances in Integrative Anatomy and Evolutionary Biology, 291(6), 714-720.

Starr M, Saiyo H. Sepsis in old ages: Review of human and animal studies. 2014. Available from: www.ncbi.nlm. nih.gov/pmc/articles/PMC3966671/?repo rt=classic

Tambajong N. Rheza., Lalenoh C. Diana., Kumaat Lucky. 2016. Profil penderita sepsis di ICU RSUP Prof. Dr. R. D. Kandou Manadoperiode Desember 2014 – November 2015. Jurnal e-Clinic (eCl), Volume 4, Nomor 1

Tang Y-W, Schmitz JE, Persing DH, Stratton CW. Laboratory diagnosis of COVID-19: current issues and challenges. Journal of Clinical Microbiology. 2020;58(6)

Tang, B. M., Herwanto, V., & McLean, A. S. (2018). Immune paralysis in sepsis: recent insights and future development. Annual Update in Intensive Care and Emergency Medicine 2018, 13-23.

Tay, M. Z., Poh, C. M., Rénia, L., MacAry, P. A., & Ng, L. F. (2020). The trinity of COVID-19: immunity, inflammation and intervention. Nature Reviews Immunology, 20(6), 363-374.

Thomas-Rüddel, D., Winning, J., Dickmann, P., Ouart, D., Kortgen, A., Janssens, U., & Bauer, M. (2021). Coronavirus disease 2019 (COVID-19): update for anesthesiologists and intensivists March 2020. Der Anaesthesist, 70(1), 1-10.

Tjandra, Y., Rampengan, J., dan Supit, S. 2015. Pengaruh Senam Zumba Terhadap Jumlah Trombosit pada Mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi. Jurnal e-Biomedik. 3(1).

Venkata, C., Kashyap, R., Farmer, J. C., & Afessa, B. (2013). Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome. Journal of intensive care, 1(1), 1-10

Wang, H. E., Shapiro, N. I., Griffin, R., Safford, M. M., Judd, S., & Howard, G. (2012). Chronic medical conditions and risk of sepsis. PloS one, 7(10), e48307.

Wenham, C., Smith, J., & Morgan, R. (2020). COVID-19: the Gendered Impacts of the Outbreak. In The Lancet (Vol. 395, Issue 10227, pp. 846–848). https://doi.org/10.1016/S0140-6736(20)30526-2

Widjaja, J. T., Kwee, L., Giantara, A. K., Suabgiyo, H. A., Edwin, C., & Putri, R. L. (2021). Karakteristik Pasien COVID-19 Rawat Inap di RS Immanuel Bandung, Indonesia. Journal of Medicine and Health, 3(2).

Wiersinga, W. J., Leopold, S. J., Cranendonk, D. R., & van Der Poll, T. (2014). Host innate immune responses to sepsis. Virulence, 5(1), 36-44.

Yusniawati. (2020). Gambaran Jumlah Lukosit Pada Petugas Stasiun Pengisian Bahan Bakar Umum. STIKES ICMe Jombang

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Published

2024-03-06

How to Cite

Rezita Nurul Magfiroh, Nur Septia Handayani, Erlinda Widyastuti, & Belgis Belgis. (2024). Jumlah Leukosit, Trombosit, dan Kadar Kreatinin Pada Pasien Sepsis Covid-19 Di RSUD Genteng Banyuwangi Pada Periode 2020-2021. Jurnal Medika Nusantara, 2(2), 08–20. https://doi.org/10.59680/medika.v2i2.991