The Effect of Intermittent Fasting on Insulin Resistance and Lipid Metabolism
DOI:
https://doi.org/10.59680/ishel.v1i3.971Keywords:
intermittent fasting, insulin resistance, lipid metabolism, AMPK, autophagy, leptinAbstract
Dietary intervention with intermittent fasting can be a non-pharmacological management option in conditions of insulin resistance, dyslipidemia, and obesity. Intermittent fasting is an example of calorie restriction (not eating and drinking that contains calories) at predetermined times. This intermittent fasting protocol can be divided into time-restricted eating (TRE), alternative day fasting (ADF), or religious fasting. Intermittent fasting increases AMP activated protein kinase (AMPK) and triggers autophagy which has a favorable effect on glucose metabolism, namely lowering blood glucose, plasma insulin levels and homeostasis model assessment of insulin resistance (HOMA-IR). In addition, this fasting can reduce apolipoprotein B, increase apolipoprotein A, and reduce the hormone leptin which affects the decrease of LDL, increase of HDL and weight loss. Additional benefits of intermittent fasting are anti-aging, anti-inflammatory, and anticancer.
References
Roy Taylor. 2012Insulin Resistance and Type 2 Diabetes. Diabetes care.; 61 (4): 778-779. https://doi.org/10.2337/db12-0073
Ministry of Health of the Republic of Indonesia. (2017). Panduan PelaksanaanGerakan Nusantara Tekan Angka Obesitas (GENTAS).
Mandal S, Simmons N, Awan S, Chamari K, Ahmed I. Intermittent fasting: eating by the clock for health and exercise performance. BMJ Open Sport & Exerc Med [Internet]. January 1 2022;8(1):e001206. Available at: http://bmjopensem.bmj.com/content/8/1/e001206.abstract
Ganesan K, Habboush Y, Sultan S. Intermittent Fasting: The Choice for a Healthier Lifestyle. Cureus. 2018 Jul 9;10(7):e2947. doi: 10.7759/cureus.2947. PMID: 30202677; PMCID: PMC6128599.
Guyton AC; Hall JE. Buku ajar fisiologi kedokteran. Jakarta: EGC; 2016.
Sherwood L. Fisiologi Manusia: dari sel ke sistem. 6 ed. Jakarta: EGC; 2011.
Albosta M, Bakke J. Intermittent fasting: is there a role in the treatment of diabetes? A review of the literature and guide for primary care physicians. Clin Diabetes Endocrinol [Internet]. 2021;7(1):3. Available at: https://doi.org/10.1186/s40842-020-00116-1
James DE, Stöckli J, Birnbaum MJ. The aetiology and molecular landscape of insulin resistance. Nat Rev Mol Cell Biol [Internet]. 2021;22(11):751–71. Available at: https://doi.org/10.1038/s41580-021-00390-6
Yaribeygi H, Farrokhi FR, Butler AE, Sahebkar A. Insulin resistance: Review of the underlying molecular mechanisms. J Cell Physiol. June 2019;234(6):8152–61.
Samuel VT, Shulman GI. The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. J Clin Invest. January 2016;126(1):12–22.
Natesan V, Kim S-J. Lipid Metabolism, Disorders and Therapeutic Drugs - Review. Biomol Ther (Seoul). November 2021;29(6):596–604.
Erizon dan Yerizal. 2020. HDL DAN ATEROSKLEROSIS. Jurnal Human Care. Volume 5;No.4 (October, 2020): 1123-1131
Association of Indonesian Cardiovascular Specialists. (2022). Panduan Tata Laksana Dislipidemia 2022.
Patterson RE, Laughlin GA, LaCroix AZ, Hartman SJ, Natarajan L, Senger CM, et al. Intermittent Fasting and Human Metabolic Health. J Acad Nutr Diet. August 2015;115(8):1203–12.
de Cabo R, Mattson MP. Effects of Intermittent Fasting on Health, Aging, and Disease. N Engl J Med [Internet]. December 25 2019;381(26):2541–51. Available at: https://doi.org/10.1056/NEJMra1905136
Halberg N 2005. Effect of intermittent fasting and refeeding on insulin action in healthy men. J Appl Physiol (1985).doi: 10.1152/japplphysiol.00683.2005. Epub 2005 Jul 28. PMID: 16051710.
Lichtash C, Fung J, Ostoich KC, Ramos M. Therapeutic use of intermittent fasting and ketogenic diet as an alternative treatment for type 2 diabetes in a normal weight woman: a 14-month case study. BMJ Case Rep. July 2020;13(7).
Gayoso-Diz, et al. Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study. BMC Endocr Disord 13, 47 (2013). https://doi.org/10.1186/1472-6823-13-47
Yuan X, Wang J, Yang S, Gao M, Cao L, Li X, et al. Effect of Intermittent Fasting Diet on Glucose and Lipid Metabolism and Insulin Resistance in Patients with Impaired Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis. Int J Endocrinol. 2022;2022:6999907.
Anton SD, Moehl K, Donahoo WT, Marosi K, Lee SA, Mainous AG 3rd, et al. Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting. Obesity (Silver Spring). February 2018;26(2):254–68.
Finkel T. The metabolic regulation of aging. Nature Medicine. 2015;21(12):1416–1423. doi: 10.1038/nm.3998
Zang, B.-Y.; He, L.-X.; Xue, L. Intermittent Fasting: Potential Bridge of Obesity and Diabetes to Health? Nutrients 2022, 14, 981. https://doi.org/10.3390/nu14050981
Marjolein A. Wijngaarden, et al. 2013. Effects of prolonged fasting on AMPK signaling, gene expression, and mitochondrial respiratory chain content in skeletal muscle from lean and obese individuals. Am J Physiol Endocrinol Metab304: E1012–E1021, https://doi.org/10.1152/ajpendo.00008.2013
Yamamoto, Sh, et all. Autophagy Diferentially Regulates Insulin Production and insulin Sensivity. HHS Public access 2018 june 12 3286-3299.
Ahmed Adlouni,et al.1998. Beneficial effect on serum apo AI, apo B and Lp AI levels of Ramadan fasting. Clinica Chimica Acta. Volume 271, Issue 2,Pages 179-189.
Ara, T. et al. “Effect of Ramadan Fasting on Total cholesterol (TC) Low density lipoprotein cholesterol (LDL-C) and High density lipoprotein cholesterol (HDL-C) in Healthy Adult Male.” Journal of Bangladesh Society of Physiologist 10 (2016): 46-50.
Santos, Heitor. Impact of intermitten Fasting on the lipid profile: Assesment associated with diet and weight loss. Clinical Nutrition ESPEN 2018 14-21
Jeon, SM. Regulation and function of AMPK in physiology and diseases. Exp Mol Med 48, e245 (2016). https://doi.org/10.1038/emm.2016.81
