Efektivitas Senyawa Sulforaphane dari Microgreen Brokoli (Brassica Oleracea) sebagai Immunomodulator (Anti-Pyroptosis Macrophage) dan Antifibrosis Paru untuk Pengobatan Penyakit Tuberkulosis Paru
DOI:
https://doi.org/10.59680/ventilator.v4i2.2491Keywords:
Anti-Fibrosis, Brassica Oleracea, Immunomodulator, Pulmonary Tuberculosis, SulforaphaneAbstract
Pulmonary tuberculosis is a contagious infectious disease caused by Mycobacterium tuberculosis and remains one of the leading causes of death worldwide, including in Indonesia. Long-term tuberculosis treatment often results in various problems, such as drug resistance, poor patient adherence, lung tissue damage, and post-infection pulmonary fibrosis. Therefore, innovative natural-based therapeutic approaches are needed to improve treatment effectiveness while minimizing complications. This study aims to examine the potential of sulforaphane (SFN), a phytochemical compound derived from broccoli microgreens (Brassica oleracea), as an immunomodulatory and anti-pulmonary fibrosis agent through nanoencapsulation technology. This study employed a narrative literature review method using scientific databases, including PubMed, Scopus, ScienceDirect, and Google Scholar, covering publications from 2018–2024. Data were analyzed using critical appraisal techniques to systematically evaluate and synthesize previous findings. The review demonstrated that SFN exhibits antioxidant activity by activating the NRF2 signaling pathway, thereby reducing reactive oxygen species (ROS) production, inhibiting NLRP3 inflammasome activation, and preventing macrophage pyroptosis induced by M.
References
Acharya, B., Acharya, A., Gautam, S., Ghimire, S. P., Mishra, G., Parajuli, N., & Sapkota, B. (2020). Advances in diagnosis of Tuberculosis: An update into molecular diagnosis of Mycobacterium tuberculosis. Molecular Biology Reports, 47(5), 4065–4075. https://doi.org/10.1007/s11033-020-05413-7
Alsayed, S. S. R., & Gunosewoyo, H. (2023). Tuberculosis: Pathogenesis, Current Treatment Regimens and New Drug Targets. International Journal of Molecular Sciences, 24(6), 5202. https://doi.org/10.3390/ijms24065202
Chen, G., Shen, L., Hu, H., Feng, Y., Wen, D., Liu, Y., Zhai, H., Sun, W., Wang, M., Lei, X., Li, P., Xiong, Q., & Wu, C. (2024). Sulforaphane Inhibits Oxidative Stress and May Exert Anti-Pyroptotic Effects by Modulating NRF2/NLRP3 Signaling Pathway in Mycobacterium tuberculosis-Infected Macrophages. Microorganisms, 12(6), 1191. https://doi.org/10.3390/microorganisms12061191
Collins, Á. B., Floyd, S., Gordon, S. V., & More, S. J. (2022). Prevalence of Mycobacterium bovis in milk on dairy cattle farms: An international systematic literature review and meta-analysis. Tuberculosis, 132, 102166. https://doi.org/10.1016/j.tube.2022.102166
Directorate General for Disease Control and Prevention Ministry of Health of the Republic of Indonesia. (2023). The 2022 Annual Report on the National TB Program.
Eni Susilawati & Budi P. Soewondo. (2022). Pengaruh Nanoenkapsulasi pada Aktivitas Senyawa yang Berpotensi sebagai Antioksidan. Jurnal Riset Farmasi, 1–8. https://doi.org/10.29313/jrf.v2i1.692
Global Tuberculosis Report 2023. (2023). World Health Organization.
Kaiser, A. E., Baniasadi, M., Giansiracusa, D., Giansiracusa, M., Garcia, M., Fryda, Z., Wong, T. L., & Bishayee, A. (2021). Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential. Cancers, 13(19), 4796. https://doi.org/10.3390/cancers13194796
Kyung, S. Y., Kim, D. Y., Yoon, J. Y., Son, E. S., Kim, Y. J., Park, J. W., & Jeong, S. H. (2018). Sulforaphane attenuates pulmonary fibrosis by inhibiting the epithelial-mesenchymal transition. BMC Pharmacology and Toxicology, 19(1), 13. https://doi.org/10.1186/s40360-018-0204-7
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