Implication of Thrombus Marker (D-Dimer) Levels in Preeclamptic Pregnant Women During the Third Trimester
DOI:
https://doi.org/10.59680/ishel.v3i1.1765Keywords:
D- Dimer, Microvasculature, Preeclampsia, Thrombus MarkerAbstract
Microvasculature fibrin deposition is implicated in preeclampsia. D-Dimer has emerged as a useful diagnostic tool for thrombotic conditions because its plasma concentration has a high negative implicative value for veinous thromboembolism. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of twenty (20) normotensive and twenty (20) preeclamptic pregnant women in their third trimester of pregnancy. Blood samples was spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes after which plasma was collected and stored frozen in plain sample bottles and was analyzed for thrombus marker (D- Dimer) levels by fluorescence immunoassay method.
References
1. Raia-Barjat, T., Edebiri, O., & Ni Ainle, F. (2022). Preeclampsia and venous thromboembolism: Pathophysiology and potential therapy. Frontiers in Cardiovascular Medicine, 9, 856923.
2. Armaly, Z., Jadaon, J. E., Jabbour, A., & Abassi, Z. A. (2018). Preeclampsia: Novel mechanisms and potential therapeutic approaches. Frontiers in Physiology, 9, 973.
3. Duley, L. (2009, June). The global impact of pre-eclampsia and eclampsia. In Seminars in Perinatology (Vol. 33, No. 3, pp. 130-137). WB Saunders.
4. Asmanidar, A., & Emilda, E. (2024). Optimizing maternal healthcare: Holistic strategies for early detection and management of preeclampsia. Science Midwifery, 12(1), 158-167.
5. Wauthier, L., Favresse, J., Hardy, M., Douxfils, J., Le Gal, G., Roy, P. M., ... & Mullier, F. (2023). D-dimer testing: A narrative review. Advances in Clinical Chemistry, 114, 151-223.
6. Monisha, M. (2022). A study on the association of elevated D-dimer levels and the extent of severity of preeclampsia (Doctoral dissertation, Stanley Medical College, Chennai).
7. Xu, C., Li, Y., Zhang, W., & Wang, Q. (2021). Analysis of perinatal coagulation function in preeclampsia. Medicine, 100(26), e26482.
8. Adam, S. S., Key, N. S., & Greenberg, C. S. (2009). D-dimer antigen: Current concepts and future prospects. Blood, 113(13), 2878-2887.
9. Steegers, E. A., von Dadelszen, P., Duvekot, J. J., & Pijnenborg, R. (2010). Preeclampsia. The Lancet, 376(9741), 631-644.
10. Lim, K. H., Zhou, Y., Janatpour, M., McMaster, M., Bass, K., Chun, S. H., & Fisher, S. J. (1997). Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia. The American Journal of Pathology, 151(6), 1809-1818.
11. Gong, L., Zhao, D., Li, X., Wang, J., & Yu, Y. (2016). D-dimer as a biomarker for assessing progression to overt preeclampsia in women with gestational hypertension. Hypertension in Pregnancy, 35(4), 426-433.
12. Rodger, M. A., Betancourt, M. T., Clark, P., Lindqvist, P. G., Dizon-Townson, D., Said, J., et al. (2010). The role of thrombophilia testing in pregnancy. Journal of Thrombosis and Haemostasis, 8(5), 919-929.
13. Buhimschi, C. S., Funai, E. F., & Buhimschi, I. A. (2011). Clinical significance of coagulation abnormalities in preeclampsia. Clinics in Perinatology, 38(1), 101-114.
