Formulasi Dan Uji Fisikokimia Gel Sleeping Mask Ekstrak Kulit Buah Naga Merah Dengan Variasi Gelling Agent Hydroxypropyl Methly Cellulose (HPMC)
DOI:
https://doi.org/10.59680/medika.v1i2.273Keywords:
Gel Sleeping Mask, HPMC, Red Dragon Fruit Peel, Physicochemical TestAbstract
Gels are semi-solid preparations formed from suspensions made up of large organic molecules and small inorganic particles that permeate the liquid. Sleeping mask It is a skin care product that is used at night (before going to bed). Serious research on natural ingredients is currently being carried out, including research in the field of cosmetics. Among the advantages of natural ingredients is their antioxidant properties, which can disrupt free radicals and cause the use of antioxidants in preventing premature aging. Dragon fruit skin contains compounds polyphenol, anthocyanins and betacyanins which have antioxidant activity. This study aims to determine the effect of the gelling agent Hydroxypropyl Methylcellulose (HPMC) on the physical properties of gel preparations sleeping mask red dragon fruit skin extract. This study uses an experimental method. Red dragon fruit skin is extracted by maceration in 96% ethanol. This study used 3 gel formulations, with various concentrations of HPMC 5%, 7% and 9%. Physicochemical tests carried out included organoleptic tests, homogeneity, pH, spreadability, adhesion, irritation and viscosity. The results of the research show the use of variations gelling agent HPMC meets the criteria for the physicochemical test of gel preparations sleeping mask from dragon fruit skin extract which produces the best formula from gel preparations sleeping mask namely formulation III (9%) has the best evaluation.
References
Ali, N. W., Yamlean, P. V. Y., & Kojong, N. S. (2015). Pengaruh Perbedaan Tipe Basis terhadap Sifat Fisik Sediaan Salep Ekstrak Etanol Daun Tapak Kuda (Ipomoea Pes-Caprae (L) Sweet). Jurnal Ilmiah Farmasi-UNSRAT, 4(3), 110–116.
Ansel, H. C. (1989). Pengantar Bentuk Sediaan Farmasi. UI Prees.
Indrawan. (2015). Formulasi Sediaan Masker Gel Menggunakan Ekstrak Daun Jambu Biji (Psidium Guajava. L). Karya Tulis Ilmiah.
Irsan, Manggau, M., & Pakki, E. (2013). Uji Iritasi Krim Antioksidan Ekstrak Biji Lengkeng (Euphoria longana Stend) Pada Kulit Kelinci (Oryctolagus cuniculus). Majalah Farmasi Dan Farmakologi, 17 (2)(6).
Jaafar, R. A., Abdul Rahman, A. R. Bin, Mahmod, N. Z. C., & Vasudevan, R. (2009). Proximate analysis of dragon fruit (Hylecereus polyhizus). American Journal of Applied Sciences, 6(7). https://doi.org/10.3844/ajassp.2009.1341.1346
Marian, E. I., Mocko, T. K., Bojnaska, T., Marcek, J., & Mendelova, A. (2013). Antioxidant Activity Of Selected Plant Products. Journal of Microbiology, Biotechnology and Food Sciences, 2(1).
Nurahmanto, D., Mahrifah, I. R., Azis, R. F. N. I., & Rosyidi, V. A. (2017). Formulasi Sediaan Gel Dispersi Padat Ibuprofen?: Studi Gelling Agent Dan Senyawa Peningkat Penetrasi. Jurnal Ilmiah Manutung, 3(1).
Nurdianti, L., Rosiana, D., & Aji, N. (2018). Evaluasi Sediaan Emulgel Anti Jerawat Tea Tree (Melaleuca Alternifolia) Oil Dengan Menggunakan Hpmc Sebagai Gelling Agent. Journal of Pharmacopolium, 1(1).
Peter Elsner, & Maibach, H. (2000). Cosmeceuticals and Active Cosmetics Drugs Versus Cosmetics Second Edition. In E. JUNGERMANN (Ed.), Cosmetic Science and Technology Series. University of Jena, Germany.
Prastiyani, H. (2021). Uji Kadar Flavonoid Total dan Aktivitas Antioksidan Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus ). Skripsi.
Rinaldi, Fauziah, & Zakaria, N. (2021). Studi Formulasi Sediaan Gel Ekstrak Etanol Serai Wangi ( Cymbopogon nardus (L.) Randle) dengan Basis HPMC. Jurnal Ilmiah Farmasi Simplisia, 1(1), 33-42 ISSN:27754510.
Rowe, R. C., Sheskey, paul J., & Quinn, M. E. (2009). Pharmaceutical excipients. In Remington: The Science and Practice of Pharmacy. https://doi.org/10.1016/B978-0-12-820007-0.00032-5
Silvia, B. M., Dewi, M. L., & Darusman, F. (2021). Studi Literatur Pengaruh Jenis dan Konsentrasi Basis terhadap Karakteristik Masker Gel Peel Off. Jurnal Riset Farmasi (JRF), 1(2). http://journals.unisba.ac.id/index.php/JRF
Simon, P. (2012). Formulasi Dan Uji Penetrasi Mikroemulsi Formulasi Dan Uji Penetrasi Mikroemulsi Ji Natrium Diklofenak Dengan Metode Sel Difusi Natrium Diklofenak Dengan Metode Sel Difusi Franz Dan Metode Franz Dan Metode Tape Stripping. Skrips.
Syaiful, S. D. (2016). Formulasi Dan Uji Stabilitas Fisik Gel Ekstrak Etanol Daun Kemangi (Ocimum Sanctum L.) Sebagai Sediaan Hand Sanitizer. Skripsi, June.
Ulaen, S., Banne, Y., & Suatan, R. (2012). Pembuatan Salep Anti Jerawat Dari Ekstrak Rimpang Temulawak (Curcuma xanthorrhiza Roxb.). Jurnal Ilmiah Farmasi Poltekkes Manado, 3(2). https://www.neliti.com/publications/96587/pembuatan-salep-anti-jerawat-dari-ekstrak-rimpang-temulawak-curcuma-xanthorrhiza#cite
Utami, Y. P., Umar, A. H., Syahruni, R., & Kadullah, I. (2017). Standardisasi Simplisia dan Ekstrak Etanol Daun Leilem ( Clerodendrum minahassae Teisjm. & Binn.). Journal of Pharmaceutical and Medicinal Sciences, 2(1), 32–39.
Wu, L. C., Hsu, H. W., Chen, Y. C., Chiu, C. C., Lin, Y. I., & Ho, J. A. A. (2006). Antioxidant and antiproliferative activities of red pitaya. Food Chemistry, 95(2). https://doi.org/10.1016/j.foodchem.2005.01.002
Yang, L. (2019). The Korean Skincare Bible. In Paper Knowledge . Toward a Media History of Documents (Vol. 3, Issue April).
Yusuf, A. L., Nurawaliah, E., & Harun, N. (2017). Uji efektivitas gel ekstrak etanol daun kelor (Moringa oleifera L.) sebagai antijamur Malassezia furfur. Kartika?: Jurnal Ilmiah Farmasi, 5(2). https://doi.org/10.26874/kjif.v5i2.119
