Gambaran Histopatologi Telinga Tengah Tikus Model Otitis Media Supuratif Kronis yang Diinduksi oleh Bakteri Pseudomonas aeruginosa : Studi terhadap Ketebalan Membran Timpani, Kerusakan Epitel, Derajat Inflamasi, dan Sklerosis

Cut Triannisa Sharitsa; Devira Zahara; Devi Nafilah Yuzar; Taufik Ashar

doi:10.59680/anestesi.v4i3.2562

Gambaran Histopatologi Telinga Tengah Tikus Model Otitis Media Supuratif Kronis yang Diinduksi oleh Bakteri Pseudomonas aeruginosa

Studi terhadap Ketebalan Membran Timpani, Kerusakan Epitel, Derajat Inflamasi, dan Sklerosis

Authors

Cut Triannisa Sharitsa Universitas Sumatera Utara
Devira Zahara Universitas Sumatera Utara
Devi Nafilah Yuzar Universitas Sumatera Utara
Taufik Ashar Universitas Sumatera Utara

DOI:

https://doi.org/10.59680/anestesi.v4i3.2562

Keywords:

Chronic Suppurative Otitis Media, Histopathology, Pseudomonas Aeruginosa, Tympanic Membrane, Wistar Rat

Abstract

Chronic suppurative otitis media (CSOM) is a chronic middle ear inflammation characterized by persistent tympanic membrane perforation and prolonged otorrhea, predominantly caused by Pseudomonas aeruginosa. This study aimed to evaluate the histopathological features of middle ear tissue in a rat model of CSOM induced by P. aeruginosa. This experimental study with a post-test only control group design used male Wistar Rattus norvegicus rats divided into a Sham group (S1) and a P. aeruginosa-induced group (S2). Induction was performed through bilateral tympanic membrane perforation and transcanal inoculation of 0.1

References

Artono, A., Purnami, N., Handoko, E., Widodo, A. D. W., & Juniastuti, J. (2025). Pseudomonas aeruginosa in chronic suppurative otitis media. Infection & Chemotherapy, 57(1), 63. https://doi.org/10.3947/ic.2024.0062

Assiri, K., Hudise, J., & Obeid, A. (2024). Risk factors for chronic and recurrent otitis media in children: A review article. Indian Journal of Otolaryngology and Head & Neck Surgery, 76(1), 1464–1469. https://doi.org/10.1007/s12070-023-04256-5

Beig, S., Khalid, S., & Sharma, S. C. (2020). Radiographic imaging of mastoid in chronic otitis media: Need or tradition? International Journal of Otorhinolaryngology and Head and Neck Surgery, 6(9), 1592. https://doi.org/10.18203/issn.2454-5929.ijohns20203491

Bhutta, M. F., Leach, A. J., & Brennan-Jones, C. G. (2024). Chronic suppurative otitis media. The Lancet, 403(10441), 2339–2348. https://doi.org/10.1016/S0140-6736(24)00259-9

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Published

2026-07-02

How to Cite

Cut Triannisa Sharitsa, Devira Zahara, Devi Nafilah Yuzar, & Taufik Ashar. (2026). Gambaran Histopatologi Telinga Tengah Tikus Model Otitis Media Supuratif Kronis yang Diinduksi oleh Bakteri Pseudomonas aeruginosa : Studi terhadap Ketebalan Membran Timpani, Kerusakan Epitel, Derajat Inflamasi, dan Sklerosis. Jurnal Anestesi, 4(3), 253–268. https://doi.org/10.59680/anestesi.v4i3.2562

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Issue

Vol. 4 No. 3 (2026): Juli: Jurnal Anestesi: Jurnal Ilmu Kesehatan dan Kedokteran

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Articles

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