Scoping Review: Eksplorasi Potensi Senyawa Mangiferin dengan Efek Kardioprotektif sebagai Agen Terapi Terbarukan Penyakit Kardiovaskular
DOI:
https://doi.org/10.59680/anestesi.v4i2.2363Keywords:
Bioactive Compound, Cardioprotective Effect, Cardiovascular Disease, Mangiferin, Scoping ReviewAbstract
Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide, with increasing incidence among young adults due to unhealthy lifestyles and metabolic risk factors. Current pharmacological therapies face limitations, including suboptimal efficacy and adverse effects, highlighting the need for novel therapeutic agents. Mangiferin, a natural polyphenolic compound derived from Mangifera indica, has recently gained attention for its potential cardioprotective properties. This study aimed to explore the cardioprotective effects of mangiferin and its underlying mechanisms in cardiovascular diseases. This research employed a scoping review approach by systematically identifying and analyzing experimental studies published between 2020 and 2025 from databases such as Google Scholar and ResearchGate. Articles were selected based on predefined inclusion and exclusion criteria, focusing on studies investigating the cardioprotective effects of mangiferin. The findings indicate that mangiferin exerts significant cardioprotective effects through antioxidant and anti-inflammatory mechanisms. It enhances cellular antioxidant defense by activating the PI3K/AKT/Nrf2 signaling pathway, suppresses inflammatory responses by inhibiting NF-kB and cGAS-STING pathways, and reduces apoptosis. Additionally, mangiferin improves endothelial cell viability, decreases oxidative stress biomarkers, lowers pro-inflammatory cytokines, and enhances cardiac function in experimental models. In conclusion, mangiferin demonstrates strong potential as a novel plant-derived therapeutic agent for cardiovascular diseases. Its multi-targeted mechanisms support its role in protecting cardiovascular tissues. However, further clinical studies are required to validate its efficacy, safety, optimal dosage, and bioavailability in humans, as well as to support its development into standardized therapeutic formulations.
References
Astuti, H. Y., Ismail, S., & Johan, A. (2022). Nurses’ Resilience During Covid-19 Pandemic: A Scoping Review. International Journal of Nursing and Health Services (IJNHS), 5(1), 88–95. https://doi.org/10.35654/ijnhs.v5i1.566
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., Delling, F. N., Djousse, L., Elkind, M. S. V., Ferguson, J. F., Fornage, M., Jordan, L. C., Khan, S. S., Kissela, B. M., Knutson, K. L., … Virani, S. S. (2019). Heart disease and stroke statistics—2019 update: A report from the American Heart Association. Circulation, 139(10), e56–e528. https://doi.org/10.1161/CIR.0000000000000659
Bhatia, J., Suchal, K., Bhargava, P., Malik, S., & Arya, D. (2021). EVALUATION OF THE CARDIOPROTECTIVE EFFECT OF MANGIFERIN IN AN EXPERIMENTAL MODEL OF ISCHEMIA REPERFUSION INJURY. Journal of Hypertension, 39(Supplement 1), e280. https://doi.org/10.1097/01.hjh.0000747668.48915.20
Hidayati, E. H., Yuniati, R., Lestari, R., Jumari, J., & Walujo, E. B. (2024). Mangifera spp. In the Ethnoclimatology Study of Tatangar Banjar Tradition in Kalimantan. Jurnal Biodjati, 9(2), 244–258. https://doi.org/10.15575/biodjati.v9i2.30048
Imran, M., Arshad, M. S., Butt, M. S., Kwon, J. H., Arshad, M. U., & Sultan, M. T. (2017). Mangiferin: A natural miracle bioactive compound against lifestyle related disorders. Lipids in Health and Disease, 16(1), 84. https://doi.org/10.1186/s12944-017-0449-y
Ismail, M. B., Rajendran, P., AbuZahra, H. M., & Veeraraghavan, V. P. (2021). Mangiferin Inhibits Apoptosis in Doxorubicin-Induced Vascular Endothelial Cells via the Nrf2 Signaling Pathway. International Journal of Molecular Sciences, 22(8), 4259. https://doi.org/10.3390/ijms22084259
Jiang, T., Han, F., Gao, G., & Liu, M. (2020). Mangiferin exert cardioprotective and anti-apoptotic effects in heart failure induced rats. Life Sciences, 249, 117476. https://doi.org/10.1016/j.lfs.2020.117476
Matkowski, A., Kus, P., Goralska, E., & Wozniak, D. (2013). Mangiferin—A bioactive xanthonoid, not only from mango and not just antioxidant. Mini-Reviews in Medicinal Chemistry, 13(3), 439–455. https://doi.org/10.2174/1389557511313030008
Minniti, G., Laurindo, L. F., Machado, N. M., Duarte, L. G., Guiguer, E. L., Araujo, A. C., Dias, J. A., Lamas, C. B., Nunes, Y. C., Bechara, M. D., Baldi Júnior, E., Gimenes, F. B., & Barbalho, S. M. (2023). Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review. Life, 13(12), 2270. https://doi.org/10.3390/life13122270
Narkhede, M., Pardeshi, A., Bhagat, R., & Dharme, G. (2024). Review on Emerging Therapeutic Strategies for Managing CardiovascularDisease. Current Cardiology Reviews, 20(4), e160424228949. https://doi.org/10.2174/011573403X299265240405080030
Netala, V. R., Teertam, S. K., Li, H., & Zhang, Z. (2024). A Comprehensive Review of Cardiovascular Disease Management: Cardiac Biomarkers, Imaging Modalities, Pharmacotherapy, Surgical Interventions, and Herbal Remedies. Cells, 13(17), 1471. https://doi.org/10.3390/cells13171471
Popa, A., Usatiuc, L.-O., Scurtu, I. C., Murariu, R., Cofaru, A., Pop, R., Tabaran, F. A., Gherman, L. M., Valean, D., Bolundut, A. C., Orzan, R. I., Muresan, X. M., Morohoschi, A. G., Andrei, S., Lazea, C., & Agoston-Coldea, L. (2024). Assessing the Anti-Inflammatory and Antioxidant Activity of Mangiferin in Murine Model for Myocarditis: Perspectives and Challenges. International Journal of Molecular Sciences, 25(18), 9970. https://doi.org/10.3390/ijms25189970
Retnaningtyas, Y., Kristiningrum, N., Renggani, H. D., & Sary, I. P. (2020). Stability Indicating RP-HPLC for Quantification Mangiferin in Extract of Three Species Mango Leaves. Indonesian Journal of Chemical Research, 8(1), 15–20. https://doi.org/10.30598/ijcr.2020.8-yun
Song, J., Wang, M., Li, Q., Zhao, W., Chen, X., Li, C., & Guo, Q. (2026). Mangiferin inhibits cGAS-STING pathway-related inflammation via Nrf2 activation to protect against sepsis-induced heart injury. Chinese Medicine, 21(1), 47. https://doi.org/10.1186/s13020-026-01329-9
Upadhyay, S., & Dixit, M. (2015). Role of polyphenols and other phytochemicals on molecular signaling. Oxidative Medicine and Cellular Longevity, 2015, 504253. https://doi.org/10.1155/2015/504253
World Health Organization. (2023). Cardiovascular diseases (CVDs). World Health Organization. https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
Zhao, D. (2021). Epidemiological Features of Cardiovascular Disease in Asia. JACC: Asia, 1(1), 1–13. https://doi.org/10.1016/j.jacasi.2021.04.007
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Naufal Issan Beryldivito Iskandar
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
