Efek Kava (Piper Methysticum) Sebagai Anestesi
DOI:
https://doi.org/10.59680/ventilator.v3i1.1737Keywords:
Kava, Piper methysticum, Anesthesia, Kavalactones, Central nervous system, Systematic review, Meta-analysisAbstract
Kava (Piper Methysticum) is a plant traditionally used in the South Pacific for its sedative and anxiolytic effects. Its active compounds, kavalactones, are known to have potential as natural anesthetics, with a mechanism of action similar to benzodiazepines and general anesthetics. This study aims to evaluate the effectiveness of Kava as an anesthetic through a systematic literature review and meta-analysis. Literature searches were conducted in PubMed, Scopus, and Cochrane Library using relevant keywords. Meta-analysis results indicate that Kava significantly enhances anesthetic effects compared to placebo, primarily through modulation of GABA-A receptors. However, further research is needed to determine the optimal dosage and long-term safety.
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