Uji Aktivitas Sediaan Sabun Padat Kombinasi Ekstrak Daun Kemangi (Ocimum Sanctum L.) dan Ekstrak Daun Bandotan (Ageratum Conyzoides Sleberex Steud) terhadap Bakteri Propionibacterium Acnes
DOI:
https://doi.org/10.59680/medika.v2i3.1292Keywords:
basil leaf extract, bandotan leaf extract, solid soap, propionibacterium acnesAbstract
Solid soap is a preparation used to clean the skin from dirt and bacteria. Basil leaves and bandotan leaves are plants that have secondary metabolites such as alkaloids, flavonoids, tannins, saponins and steroids that have the potential to be antibacterial. This study was to formulate solid soap from ethanol extract of basil leaf and bandotan leaf as an antibacterial, to determine the formulation of solid soap of bandotan leaf extract and basil extract which has the strongest inhibition zone in the bacterium Propionibacterium acnes. This research method is an experimental method by making basil leaf extract and bandotan leaf extract by maceration with 96% alcohol. Solid soap formulations are made with 3 concentration variations, namely formulation 1 basil extract 7.5% and bandotan extract 12.5%, formulation 2 basil extract 10% and bandotan extract 10% and formulation 3 basil extract 12.5% and bandotan extract 7.5%. Then the antibacterial activity of solid soap was tested with Propionibacterium acnes bacteria by the well dilution method. Conclusion The formulation of basil leaf extract and bandotan leaf extract has antibacterial activity, solid soap preparations from basil leaf extract and bandotan leaf extract have met the quality requirements, in formulations 2 and 3 basil leaf extract and bandotan leaf extract have a strong inhibition zone of 6.7 mm. Then the data was analyzed using one way ANOVA.
References
Alydrus, Lia Novita, Sabaniah Indjar Gama & Laode Rijai. 2023. “Skrining Fitokimia Dan Uji Aktivitas Antibakteri Ekstrak Daun Bidara (Ziziphus Mauritiana) Terhadap Bakteri Propionibacterium Acnes.” Proceeding of Mulawarman Pharmaceuticals Conferences 17: 38–43.
Ariani, Nita, Nahar & Selvie Diana. 2022. “Pembuatan Hand And Body Lotion Dari Ekstrak Rimpang Kunyit Dengan Menggunakan Metode Maserasi.” 1(2): 48–51.
Arif, M Rizky, Elly Purwati & Cikra Ihda Nhs. 2021. “Formulasi Dan Uji Mutu Fisik Sediaan Sabun Padat Herbal Ekstrak Daun Ubi Jalar Ungu ( Ipomea Batatas L ) Dengan Penambahan Madu.” : 453–59.
Aris, Muhammad, Andi Nur, Ilmi Adriana, and Leo Arif Prasetyadi. 2021. “Uji Efektivitas Formula Sediaan Sabun Padat Sari Daun Kelor ( Moringa Oleifera L ) Asal Daerah Takalar Terhadap Staphylococcus Aureus.” 13: 1–9.
Daud, Nur Saadah, and Sri Aprilianti Idris. 2023. “Uji Aktivitas Antibakteri Ekstrak Batang Meistera Chinensis Terhadap Escherichia Coli ATCC 35218 Antibacterial Activity Test of Extract from Meistera Chinensis Stem Against Escherichia Coli Atcc 35218.” 12: 8–18.
Fadhila, Zulfa Nur et al. 2019. “Penetapan Parameter Spesifik Dan Non Spesifik Ekstrak Kulit Semangka.” Jurnal Insan Farmasi Indonesia 5(1): 159–66.
Fitri, Annisa Salma, Delia Komala Sari, and Teja Dwi Sutanto. 2023. “Formulasi Sabun Padat Dengan Menggunakan Ekstrak Kunyit ( Curcuma Domestica L .).” 3.
Haryati, Eti, Siti Pandanwangi TW, Esra Reinanda Nabila, and Nurpatmawati Nurpatmawati. 2023. “Pembuatan Media Pertumbuhan Bakteri Menggunakan Tepung Biji Nangka (Artocarpus Heterophyllus Lamk) Untuk Pertumbuhan Bakteri Staphylococcus Aureus.” Praeparandi?: Jurnal Farmasi Dan Sains 7(1): 1
Hasby, Adeliana. 2021. “Analisis Pengaruh Lama Perendaman Dengan Menggunakan Larutan Daun Salam (Syzygium Polyanthum) Terhadap Kualitas Fisik Daging Ikantongkol (Euthynnus Affinis) Rifvia.” 4(1): 1–8.
Mardiayanti siti, naya luthya aisyah nabila. 2021. “PharmaCine Journal of Pharmacy, Medical and Health Science.” Uji Stabilitas Krim Ekstrak Daun Kemangi (Ocimum americanum L.) dan Uji Antibakteri Terhadap Propionibacterium acnes Penyebab Jerawat 02(September): 51–68
Martinus, B.A., and Verawati Verawati. 2016. “Penentuan Kadar Flavonoid Total Dan Aktivitas Antioksidan Dari Ekstrak Daun Bandotan (Ageratum Conyzoides L.).” Scientia?: Jurnal Farmasi dan Kesehatan 5(1): 47.
Mopangga, Elisticia, Paulina V Y Yamlean, and Surya Sumantri Abdullah. 2021. “Formulation Of Solid Bath Soap With Ethanol Extract Of Gedi Leaves ( Abelmoschus Manihot L .) To Staphylococcus Epidermidis Bacteria Formulasi Sediaan Sabun Mandi Padat Ekstrak Etanol Daun Gedi ( Abelmoschus Manihot L .) Terhadap Bakteri Staphylococcus Ep.” 10: 1017–24.
Munawwarah, Andalia, Fauziah, Adriana. 2021. “Formulasi Sediaan Sabun Padat Transparan Dari Ekstrak Etanol Daun Sisik Naga (Pyrrosia Piloselloides L).” Jurnal Sains dan Kesehatan Darussalam 1(2): 51–57.
Novitasari, Helma, Siti Nashihah, and Irfan Zamzani. 2021. “Identifikasi Daun Sangkareho (Callicarpa Longifolia Lam) Secara Makroskopis Dan Mikroskopis.” Jurnal Sains dan Kesehatan 3(5): 667–72.
Nurhayati, Lilih Siti, Nadhira Yahdiyani, and Akhmad Hidayatulloh. 2020. “Perbandingan Pengujian Aktivitas Antibakteri Starter Yogurt Dengan Metode Difusi Sumuran Dan Metode Difusi Cakram.” Jurnal Teknologi Hasil Peternakan 1(2): 41
Oktavia, Sutoyo. 2021. “Skrining Fitokimia, Kandungan Flavonoid Total, Dan Aktivitas Antioksidan Ekstrak Etanol Tumbuhan Selaginella Doederleinii Farida Dwi Oktavia, Suyatno Sutoyo *.” 6(2): 141–53
Putri, Risky Juliansyah et al. 2023. “Formulasi Dan Uji Aktivitas Antiacne Sediaan Sabun Padat Ekstrak Batang Pisang Ambon ( Musa Paradisiaca Var . Sapientum ) Terhadap Bakteri Propionibacterium Acnes.” (20): 20–24.
Ramadani, nurhalisa, Putri. 2024. “Efektivitas Sediaan Serum Wajah Ekstrak Rambut Jagung (Zea Mays L.) Terhadap Propionibacterium Acnes.” 8(1): 58–66.
Rizka, Ramaza et al. 2017. “Uin Syarif Hidayatullah Jakarta Formulasi Sabun Padat Kaolin Penyuci Najis Mughalladzah Dengan Variasi Konsentrasi Minyak Kelapa Dan Asam Stearat.”
Sanjiwani, Mendra, Sudharmayasa. 2024. “Pengujian Mutu Fisik Formulasi Sediaan Sabun Padat Berbahan Susu Kedelai.” Emasains?: Jurnal Edukasi Matematika dan Sains 13(1): 96–104.
Septiandari, Vivin Kurnia, Dwi Wahyuni, and Siti Murdiyah. 2014. “Pengaruh Ekstrak Daun Kemangi ( Ocimum Americanum L .) Terhadap Pertumbuhan Bakteri Propionibacterium Acne.” : 512–18.
Sinuraya, Theresia U, Franciscus S Pranata, And Yuliana R Swasti. 2024. “AGRITEKNO?: Jurnal Teknologi Pertanian Kualitas Biskuit Kombinasi Tepung Uwi Ungu ( Dioscorea Alata ) Dan Tempe Kacang Merah ( Phaseolus Vulgaris L .) Quality Of Biscuit With Combination Of Purple Yam Flour ( Dioscorea Alata ) And Red Beans Tempeh Flour (.” 13(November 2023): 42–54
Thomas, Nur Ain et al. 2022. “Pengaruh Variasi Konsentrasi Ekstrak Buah Mahkota Dewa ( Phaleria Macrocarpa ) Terhadap Stabilitas Fisik Sediaan Krim.” 2(2): 143–52.
